Anti-Mouse Notch-1 Recombinant Antibody (SAA0270), FITC (MW570117)

Name: Anti-Mouse Notch-1 Recombinant Antibody (SAA0270), FITC
Brand: abinScience
SKU: MW570117
Price: 223 USD
Availability: InStock

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Каталожный номер	MW570117
Реактивность видов	Human, Mouse
Применения	ELISA, FCM
Хозяинский вид	Rat
Клоональность	Monoclonal
Изотип	IgG1, kappa
ID клона	SAA0270
Конъюгация	FITC
Цель	hN1, TAN1, NEXT, NICD, Notch 1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, NOTCH1
Уровень эндотоксинов	Please contact with the lab for this information.
Связанные продукты	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), FITC
Номер доступа	Q01705
Форма	Liquid
Буфер хранения	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Store at 4°C for 12 months. Protect from light. Do not freeze.
Фон	Neurogenic locus notch homolog protein 1 (NOTCH1) is a ~270 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.
Ссылки	1. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019. [MW570117] 2. toyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466. [MW570117]
Примечание	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse Notch-1 Recombinant Antibody (SAA0270), FITC.pdf

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