Anti-Mouse Notch-1 Recombinant Antibody (SAA0270), PerCP (MW570147)

Name: Anti-Mouse Notch-1 Recombinant Antibody (SAA0270), PerCP
Brand: abinScience
SKU: MW570147
Price: 268 USD
Availability: InStock

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Número de catálogo	MW570147
Reactividad de especies	Human, Mouse
Aplicaciones	ELISA, FCM
Especie huésped	Rat
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	SAA0270
Conjugación	PerCP
Objetivo	hN1, TAN1, NEXT, NICD, Notch 1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, NOTCH1
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), PerCP
Número de acceso	Q01705
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Neurogenic locus notch homolog protein 1 (NOTCH1) is a ~270 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus.
Referencias	1. NOTCH1 notch receptor 1 [Homo sapiens (human)] Gene ID: 4851, updated on 28-Oct-2019. [MW570147] 2. toyanova T, et al. Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6457-E6466. [MW570147]
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse Notch-1 Recombinant Antibody (SAA0270), PerCP.pdf

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