Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC (MC513137)

Name: Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC
Brand: abinScience
SKU: MC513137
Price: 290 USD
Availability: InStock

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Número de catálogo	MC513137
Reactividad de especies	Human, Mouse
Aplicaciones	ELISA, FCM
Especie huésped	Rat
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	59R1
Conjugación	APC
Objetivo	N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), APC
Número de acceso	O35516, Q61982
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Hamada, Y. et al. (1999) Development (Cambridge, England) 126, 3415-24. PMID: 10393120 2. Fukushima, H. et al. (2008) Molecular and cellular biology 28, 6402-12. PMID: 18710934
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC.pdf

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