Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC (MC513137)

Name: Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC
Brand: abinScience
SKU: MC513137
Price: 290 USD
Availability: InStock

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Aperçu

Numéro de catalogue	MC513137
Reactivité des espèces	Human, Mouse
Applications	ELISA, FCM
Espèce hôte	Rat
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	59R1
Conjugaison	APC
Cible	N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3
Niveau d'endotoxines	Please contact with the lab for this information.
Produits associés	Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), APC
Numéro d'accès	O35516, Q61982
Forme	Liquid
Tampon de stockage	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte	Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Hamada, Y. et al. (1999) Development (Cambridge, England) 126, 3415-24. PMID: 10393120 2. Fukushima, H. et al. (2008) Molecular and cellular biology 28, 6402-12. PMID: 18710934
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse Notch-2/Notch-3 Recombinant Antibody (59R1), APC.pdf

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