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Anti-Mouse PML Polyclonal Antibody (MB907014)

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Vista general
Número de catálogoMB907014
Descripción
Anti-Mouse PML Polyclonal Antibody (MB907014) is a rabbit polyclonal antibody detecting Protein PML. Suitable for Mouse.
Reactividad de especiesMouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse PML (Arg618-Gly868).
Objetivo E3 SUMO-protein ligase PML, EC:2.3.2.-, MYL, PML, PP8675, Promyelocytic leukemia protein, Protein PML, RING finger protein 71, RING-type E3 SUMO transferase PML, RNF71, TRIM19, Tripartite motif-containing protein 19
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q60953
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Protein PML is a ~98 kDa protein. Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosphorylation of ITPR3 and plays a role in the regulation of calcium homeostasis at the endoplasmic reticulum.

Nota For research use only
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Working Solution
C₂ (Working Conc.)
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Anti-Mouse PML Polyclonal Antibody

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