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| カタログ番号 | MY077014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse Polyclonal Antibody (MY077014) is a rabbit polyclonal antibody detecting BMP1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse BMP1 (Glu615-Ser848). | ||||||||
| ターゲット | Bone morphogenetic protein 1, BMP-1, 3.4.24.19, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, Bmp1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P98063 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Bone morphogenetic protein 1 (BMP1) is a ~111 kDa protein. Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation. 1. Muir, AM. et al. (2014) Human molecular genetics 23, 3085-101. PMID: 24419319 2. Wang, J. et al. (2017) Journal of dental research 96, 578-585. PMID: 28068493 3. Suzuki, N. et al. (1996) Development (Cambridge, England) 122, 3587-95. PMID: 8951074 4. Maruhashi, T. et al. (2010) The Journal of biological chemistry 285, 13294-303. PMID: 20181949 | ||||||||
| 注意事項 | For research use only. |
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