

| Каталожный номер | MP446014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse PPARGC1A Polyclonal Antibody (MP446014) is a rabbit polyclonal antibody detecting peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a. Suitable for Rat, Human, and Mouse.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse PPARGC1A (Pro529-Arg797). | ||||||||
| Цель | peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform b; Ppargc1a | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O70343 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) is a ~90 kDa protein. Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program. 1. Puigserver, P. et al. (2003) Nature 423, 550-5. PMID: 12754525 2. Rodgers, JT. et al. (2005) Nature 434, 113-8. PMID: 15744310 3. Ruas, JL. et al. (2012) Cell 151, 1319-31. PMID: 23217713 4. Puigserver, P. et al. (1998) Cell 92, 829-39. PMID: 9529258 | ||||||||
| Примечание | For research use only |
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