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| カタログ番号 | MA498014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse PTN/Pleiotrophin Polyclonal Antibody (MA498014) is a rabbit polyclonal antibody detecting PTN/Pleiotrophin in ELISA, IHC, WB. Suitable for Mus musculus, Human, Xenopus laevis, Sus scrofa, and Gallus gallus.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse PTN/Pleiotrophin (Gly60-Gly142). | ||||||||
| ターゲット | PTN/Pleiotrophin | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P63089 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Heparin-binding growth-associated molecule, HB-GAM, Heparin-binding neutrophic factor, HBNF, Osteoblast-specific factor 1, OSF-1, Ptn | ||||||||
| 背景 | Pleiotrophin (PTN) is a ~18 kDa protein. Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone. Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation. Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK or AFAP1L2 in order to activate the PI3K-AKT pathway. 1. Hienola, A. et al. (2004) Molecular and cellular neurosciences 26, 75-88. PMID: 15121180 2. Imai, S. et al. (2009) Bone 44, 785-94. PMID: 19442624 3. Kuboyama, K. et al. (2016) The Journal of biological chemistry 291, 18117-28. PMID: 27445335 4. Tang, C. et al. (2019) Neuron 101, 32-44.e6. PMID: 30497772 5. Amet, LE. et al. (2001) Molecular and cellular neurosciences 17, 1014-24. PMID: 11414790 6. Krellman, JW. et al. (2014) PloS one 9, e100597. PMID: 25000129 | ||||||||
| 注意事項 | For research use only. |
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