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| カタログ番号 | MF630014 | ||||||||
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| 説明 |
Anti-Mouse PTTG1 Polyclonal Antibody (MF630014) is a rabbit polyclonal antibody detecting PTTG1. Suitable for Mouse.
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse PTTG1 (Ala2-Ile199). | ||||||||
| ターゲット | EAP1, Esp1-associated protein, PTTG, PTTG1, Pituitary tumor-transforming gene 1 protein, Securin, TUTR1, Tumor-transforming protein 1, hPTTG | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9CQJ7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Securin (PTTG1) is a ~21 kDa protein. Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. | ||||||||
| 注意事項 | For research use only. |
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