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| カタログ番号 | MY562014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse S100A9 Polyclonal Antibody (MY562014) is a rabbit polyclonal antibody detecting S100a9 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse S100A9 (Ala2-Lys113). | ||||||||
| ターゲット | Protein S100-A9, Calgranulin-B, Leukocyte L1 complex heavy chain, Migration inhibitory factor-related protein 14, MRP-14, p14, S100 calcium-binding protein A9, S100a9, Cagb, Mrp14 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P31725 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Protein S100-A9 (S100A9) is a ~13 kDa protein. S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Also participates in regulatory T-cell differentiation together with CD69. 1. Vogl, T. et al. (2004) Blood 104, 4260-8. PMID: 15331440 2. Vogl, T. et al. (2007) Nature medicine 13, 1042-9. PMID: 17767165 3. Boyd, JH. et al. (2008) Circulation research 102, 1239-46. PMID: 18403730 4. Björk, P. et al. (2009) PLoS biology 7, e97. PMID: 19402754 5. Riva, M. et al. (2012) Immunology 137, 172-82. PMID: 22804476 6. Daitoku, H. et al. (2021) The Journal of biological chemistry 297, 101230. PMID: 34562450 7. Averill, MM. et al. (2011) Circulation 123, 1216-26. PMID: 21382888 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-S100A9 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse spleen lysate
Lane 2: Rat spleen lysate
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