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| カタログ番号 | MV244014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse Siglec-10 Polyclonal Antibody (MV244014) is a rabbit polyclonal antibody detecting Siglec-10 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse SIGLEC10/SLG2 (Gln18-Ser528). | ||||||||
| ターゲット | Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Sialic acid-binding Ig-like lectin G) (Siglec-G) (mSiglec-G) | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q80ZE3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sialic acid-binding Ig-like lectin 10 (SIGLEC10/SLG2) is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion. 1. Duong, BH. et al. (2010) The Journal of experimental medicine 207, 173-87. PMID: 20038598 2. Hoffmann, A. et al. (2007) Nature immunology 8, 695-704. PMID: 17572677 3. Pfrengle, F. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 1724-31. PMID: 23836061 4. Chen, GY. et al. (2009) Science (New York, N.Y.) 323, 1722-5. PMID: 19264983 5. Jellusova, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 3618-27. PMID: 20200274 6. Ding, Y. et al. (2016) Nature immunology 17, 1167-75. PMID: 27548433 | ||||||||
| 注意事項 | For research use only. |
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