

| Каталожный номер | MV244014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse Siglec-10 Polyclonal Antibody (MV244014) is a rabbit polyclonal antibody detecting Siglec-10 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
|
||||||||
| Реактивность видов | Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse SIGLEC10/SLG2 (Gln18-Ser528). | ||||||||
| Цель | Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Sialic acid-binding Ig-like lectin G) (Siglec-G) (mSiglec-G) | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q80ZE3 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
||||||||
| Информация об использовании продукта |
| ||||||||
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Sialic acid-binding Ig-like lectin 10 (SIGLEC10/SLG2) is a ~76 kDa protein. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling and specifically acts on B1 cells to inhibit Ca(2+) signaling, cellular expansion and antibody secretion. 1. Duong, BH. et al. (2010) The Journal of experimental medicine 207, 173-87. PMID: 20038598 2. Hoffmann, A. et al. (2007) Nature immunology 8, 695-704. PMID: 17572677 3. Pfrengle, F. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 1724-31. PMID: 23836061 4. Chen, GY. et al. (2009) Science (New York, N.Y.) 323, 1722-5. PMID: 19264983 5. Jellusova, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 3618-27. PMID: 20200274 6. Ding, Y. et al. (2016) Nature immunology 17, 1167-75. PMID: 27548433 | ||||||||
| Примечание | For research use only. |
Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.
Почта: [email protected]
Быстрый доступ
Свяжитесь с нами
+86-027-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский