

| Каталожный номер | MX905014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Mouse SLC16A1/MCT1 Polyclonal Antibody (MX905014) is a rabbit polyclonal antibody detecting Slc16a1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Реактивность видов | Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Mouse SLC16A1/MCT1 (Met195-Arg254). | ||||||||
| Цель | Monocarboxylate transporter 1, MCT 1, Solute carrier family 16 member 1, Slc16a1, Mct1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P53986 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Monocarboxylate transporter 1 (SLC16A1/MCT1) is a ~53 kDa protein. Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. 1. Pullen, TJ. et al. (2012) Diabetes 61, 1719-25. PMID: 22522610 2. Lengacher, S. et al. (2013) PloS one 8, e82505. PMID: 24367518 3. Reddy, A. et al. (2020) Cell 183, 62-75.e17. PMID: 32946811 | ||||||||
| Примечание | For research use only. |
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