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| カタログ番号 | MP741014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse SPHK2 Polyclonal Antibody (MP741014) is a rabbit polyclonal antibody detecting SPHK2 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse SPHK2 (Ile15-Gly276). | ||||||||
| ターゲット | SK2, Sphingosine kinase 2, SPHK2, SK 2, SPK 2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9JIA7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sphingosine kinase 2 (SPHK2) is a ~65 kDa protein. Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis. In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. 1. Maceyka, M. et al. (2005) The Journal of biological chemistry 280, 37118-29. PMID: 16118219 2. Olivera, A. et al. (2007) Immunity 26, 287-97. PMID: 17346996 3. Hisano, Y. et al. (2011) The Journal of biological chemistry 286, 1758-66. PMID: 21084291 4. Liu, H. et al. (2000) The Journal of biological chemistry 275, 19513-20. PMID: 10751414 5. Strub, GM. et al. (2011) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25, 600-12. PMID: 20959514 6. Sivasubramanian, M. et al. (2015) Neuroscience 290, 636-48. PMID: 25637806 7. Ravichandran, S. et al. (2019) Biochimica et biophysica acta. Molecular basis of disease 1865, 570-576. PMID: 30593892 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-SPHK2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HCT116 cell lysate
Lane 2: Raji cell lysate
Lane 3: LO2 cell lysate
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