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Anti-Mouse TICAM1 Polyclonal Antibody (MV815014)

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Número de catálogoMV815014
Descripción
Anti-Mouse TICAM1 Polyclonal Antibody (MV815014) is a rabbit polyclonal antibody detecting Ticam1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesMouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Mouse TICAM1 (Gln394-His510).
Objetivo TIR domain-containing adapter molecule 1, TICAM-1, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, TIR domain-containing adapter protein inducing IFN-beta, Ticam1, Trif
Purificación Purified by antigen affinity column.
Número de acceso Q80UF7
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

TIR domain-containing adapter molecule 1 (TICAM1) is a ~79 kDa protein. Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens.

1. Yamamoto, M. et al. (2003) Science (New York, N.Y.) 301, 640-3. PMID: 12855817
2. De Trez, C. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 839-46. PMID: 16002681
3. Zhang, Z. et al. (2011) Immunity 34, 866-78. PMID: 21703541
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Mouse TICAM1 Polyclonal Antibody

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