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| カタログ番号 | MV815014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse TICAM1 Polyclonal Antibody (MV815014) is a rabbit polyclonal antibody detecting Ticam1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse TICAM1 (Gln394-His510). | ||||||||
| ターゲット | TIR domain-containing adapter molecule 1, TICAM-1, Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta, TIR domain-containing adapter protein inducing IFN-beta, Ticam1, Trif | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q80UF7 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | TIR domain-containing adapter molecule 1 (TICAM1) is a ~79 kDa protein. Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. 1. Yamamoto, M. et al. (2003) Science (New York, N.Y.) 301, 640-3. PMID: 12855817 2. De Trez, C. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 839-46. PMID: 16002681 3. Zhang, Z. et al. (2011) Immunity 34, 866-78. PMID: 21703541 | ||||||||
| 注意事項 | For research use only. |
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