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| カタログ番号 | MP042117 |
|---|---|
| 種反応性 | Mouse |
| アプリケーション | FCM |
| 宿主種 | Rat |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | RMT4-53 |
| 抱合 | FITC |
| ターゲット | TIMD4, T-cell immunoglobulin mucin receptor 4, TIM-4, TIMD-4, T-cell membrane protein 4, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 関連製品 | Rat IgG2a, kappa Recombinant Isotype Control Antibody (RTK2758), FITC |
| アクセッション番号 | Q6U7R4 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 背景 | T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4/TIM-4) is a ~37 kDa protein. Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells. Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion. Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of STK11/PRKAA1 pathway in a phosphatidylserine-dependent mechanism. 1. Miyanishi, M. et al. (2007) Nature 450, 435-9. PMID: 17960135 2. Rodriguez-Manzanet, R. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 4706-13. PMID: 18354194 3. Mizui, M. et al. (2008) International immunology 20, 695-708. PMID: 18367551 4. Liu, W. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 990-1000. PMID: 31263038 |
| 注意事項 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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