Anti-Mouse p53 Polyclonal Antibody (MY039014)

Name: Anti-Mouse p53 Polyclonal Antibody
Brand: abinScience
SKU: MY039014
Price: 96 USD
Availability: InStock

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20ug
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Datasheet
SDS

Vista general

Número de catálogo

MY039014

Descripción

Anti-Mouse TP53/p53 Polyclonal Antibody (MY039014) is a rabbit polyclonal antibody detecting TP53 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse TP53/p53 (Met1-Asp390).

Aplicaciones probadas

Objetivo

Antigen NY-CO-13, Cellular tumor antigen p53, P53, Tumor suppressor p53, TP53, Phosphoprotein p53

Purificación

Purified by antigen affinity column.

Número de acceso

P02340

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

1. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538

2. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990

3. Vaseva, AV. et al. (2012) Cell 149, 1536-48. PMID: 22726440

4. Miki, T. et al. (2013) Nature communications 4, 2444. PMID: 24051492

Nota

For research use only.

Imágenes

Western blot

Western blot analysis was performed using anti-TP53 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HT-29 cell lysate
Lane 2: 293T cell lysate
Lane 3: Raji cell lysate