Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

Name: Anti-Mouse TREX1 Polyclonal Antibody
Brand: abinScience
SKU: MV590014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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SDS

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Número de catálogo

MV590014

Descripción

Anti-Mouse TREX1 Polyclonal Antibody (MV590014) is a rabbit polyclonal antibody detecting Trex1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Mouse

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Mouse TREX1 (Met11-Ala223).

Objetivo

Three-prime repair exonuclease 1, 3.1.11.2, 3'-5' exonuclease TREX1, Trex1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by antigen affinity column.

Número de acceso

Q91XB0

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation.

1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904

2. Mazur, DJ. et al. (2001) The Journal of biological chemistry 276, 17022-9. PMID: 11279105

3. Morita, M. et al. (2004) Molecular and cellular biology 24, 6719-27. PMID: 15254239

4. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595

5. Brucet, M. et al. (2007) The Journal of biological chemistry 282, 14547-57. PMID: 17355961

6. Brucet, M. et al. (2008) Protein science : a publication of the Protein Society 17, 2059-69. PMID: 18780819

7. Stetson, DB. et al. (2008) Cell 134, 587-98. PMID: 18724932

8. Pereira-Lopes, S. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 6128-35. PMID: 24218451

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Mouse TREX1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

Vista general

Imágenes

Referencias

Datasheet

SDS