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| カタログ番号 | MV590014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Mouse TREX1 Polyclonal Antibody (MV590014) is a rabbit polyclonal antibody detecting Trex1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse TREX1 (Met11-Ala223). | ||||||||
| ターゲット | Three-prime repair exonuclease 1, 3.1.11.2, 3'-5' exonuclease TREX1, Trex1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q91XB0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation. 1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904 2. Mazur, DJ. et al. (2001) The Journal of biological chemistry 276, 17022-9. PMID: 11279105 3. Morita, M. et al. (2004) Molecular and cellular biology 24, 6719-27. PMID: 15254239 4. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595 5. Brucet, M. et al. (2007) The Journal of biological chemistry 282, 14547-57. PMID: 17355961 6. Brucet, M. et al. (2008) Protein science : a publication of the Protein Society 17, 2059-69. PMID: 18780819 7. Stetson, DB. et al. (2008) Cell 134, 587-98. PMID: 18724932 8. Pereira-Lopes, S. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 6128-35. PMID: 24218451 | ||||||||
| 注意事項 | For research use only. |
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