Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

Name: Anti-Mouse TREX1 Polyclonal Antibody
Brand: abinScience
SKU: MV590014
Price: 168 USD
Availability: InStock

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Каталожный номер

MV590014

Описание

Anti-Mouse TREX1 Polyclonal Antibody (MV590014) is a rabbit polyclonal antibody detecting Trex1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Mouse TREX1 (Met11-Ala223).

Цель

Three-prime repair exonuclease 1, 3.1.11.2, 3'-5' exonuclease TREX1, Trex1

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Purified by antigen affinity column.

Номер доступа

Q91XB0

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation.

1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904

2. Mazur, DJ. et al. (2001) The Journal of biological chemistry 276, 17022-9. PMID: 11279105

3. Morita, M. et al. (2004) Molecular and cellular biology 24, 6719-27. PMID: 15254239

4. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595

5. Brucet, M. et al. (2007) The Journal of biological chemistry 282, 14547-57. PMID: 17355961

6. Brucet, M. et al. (2008) Protein science : a publication of the Protein Society 17, 2059-69. PMID: 18780819

7. Stetson, DB. et al. (2008) Cell 134, 587-98. PMID: 18724932

8. Pereira-Lopes, S. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 6128-35. PMID: 24218451

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Mouse TREX1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

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