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| カタログ番号 | MX210014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Mouse VLDLR (Glu440-Asn684). | ||||||||
| ターゲット | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P98156 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Very low-density lipoprotein receptor (VLDLR) is a ~96 kDa protein. Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail. This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. 1. Tacken, PJ. et al. (2000) Journal of lipid research 41, 2055-62. PMID: 11108739 2. Nguyen, A. et al. (2014) The Journal of biological chemistry 289, 1688-703. PMID: 24293365 3. Fuchigami, T. et al. (2013) Genes to cells : devoted to molecular & cellular mechanisms 18, 410-24. PMID: 23506116 4. Hack, I. et al. (2007) Development (Cambridge, England) 134, 3883-91. PMID: 17913789 | ||||||||
| 注意事項 | For research use only. |
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