中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | MP297025 |
|---|---|
| 説明 |
Anti-Mouse WDR45 Monoclonal Antibody (1A446) [1A446] (MP297025) is a mouse monoclonal antibody detecting Wdr45 in ELISA, WB. Suitable for Mouse.
Highlights
|
| 種反応性 | Mouse |
| アプリケーション | ELISA, WB |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2b |
| クローンID | 1A446 |
| 免疫原 | Recombinant Mouse WDR45 protein. |
| ターゲット | WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat domain X-linked 1, WD repeat-containing protein 45, Wdr45, DXImx38e, Wdrx1, Wipi4 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q91VM3 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | WD repeat domain phosphoinositide-interacting protein 4 (WDR45) is a ~39 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. 1. Saitsu, H. et al. (2013) Nature genetics 45, 445-9, 449e1. PMID: 23435086 2. Bakula, D. et al. (2017) Nature communications 8, 15637. PMID: 28561066 3. Maeda, S. et al. (2019) eLife 8. PMID: 31271352 |
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Mouse WDR45 Monoclonal Antibody (1A446)
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
