

| Numéro de catalogue | MA345014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse ZNRF3 Polyclonal Antibody (MA345014) is a rabbit polyclonal antibody detecting ZNRF3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Mouse ZNRF3 (Lys53-Pro207). | ||||||||
| Cible | KIAA1133, RNF203, RING-type E3 ubiquitin transferase ZNRF3, ZNRF3, RING finger protein 203, Zinc/RING finger protein 3, E3 ubiquitin-protein ligase ZNRF3 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q5SSZ7 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | E3 ubiquitin-protein ligase ZNRF3 is a ~98 kDa protein. E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification. 1. Hao, HX. et al. (2012) Nature 485, 195-200. PMID: 22575959 2. Koo, BK. et al. (2012) Nature 488, 665-9. PMID: 22895187 | ||||||||
| Note | For research use only. |
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