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Anti-MRAS Polyclonal Antibody (HB573014)

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Vista general
Número de catálogoHB573014
Descripción
Anti-MRAS Polyclonal Antibody (HB573014) is a rabbit polyclonal antibody detecting Ras-related protein M-Ras; 3.6.5.2; Ras-related protein R-Ras3; MRAS; RRAS3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant human MRAS (Met1-Gln204).
Objetivo Ras-related protein M-Ras; 3.6.5.2; Ras-related protein R-Ras3; MRAS; RRAS3
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O14807, O08989, P97538
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Ras-related protein M-Ras (MRAS) is a ~23 kDa protein. Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The formation of the SMP complex only occurs when MRAS is GTP-bound. MRAS has low intrinsic GTPase activity and may require additional factors for activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities.

1. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891
2. Higgins, EM. et al. (2017) JCI insight 2, e91225. PMID: 28289718
3. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504
4. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882
5. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509
6. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670
7. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765
Nota For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Mass
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Concentration
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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