Please ensure Javascript is enabled for purposes of website accessibility
Главная > Продукты > Антитела > Первичные Антитела
Цена(USD): --
Спецификация:
  • 50ug
  • 100ug
Количество:
Свяжитесь с нами
  • Обзор

  • Изображения

  • Ссылки

  • Даташит

  • SDS

Обзор
Каталожный номерHB573014
Описание
Anti-MRAS Polyclonal Antibody (HB573014) is a rabbit polyclonal antibody detecting Ras-related protein M-Ras; 3.6.5.2; Ras-related protein R-Ras3; MRAS; RRAS3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Реактивность видовHuman, Mouse, Rat
ПримененияELISA, IHC, WB
Хозяинский видRabbit
КлоональностьPolyclonal
ИзотипIgG
Иммуноген E. coli - derived recombinant human MRAS (Met1-Gln204).
Цель Ras-related protein M-Ras; 3.6.5.2; Ras-related protein R-Ras3; MRAS; RRAS3
Уровень эндотоксинов Please contact with the lab for this information.
Очистка Purified by antigen affinity column.
Номер доступа O14807, O08989, P97538
Форма Liquid
Буфер хранения 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта
Применение Разбавление
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

Ras-related protein M-Ras (MRAS) is a ~23 kDa protein. Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The formation of the SMP complex only occurs when MRAS is GTP-bound. MRAS has low intrinsic GTPase activity and may require additional factors for activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities.

1. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891
2. Higgins, EM. et al. (2017) JCI insight 2, e91225. PMID: 28289718
3. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504
4. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882
5. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509
6. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670
7. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765
Примечание For research use only
Изображения
Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Рекомендация

Свяжитесь с нами для индивидуальных предложений, оптовых запросов и других вопросов.

Почта: [email protected]

Список дистрибьюторов