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| カタログ番号 | VK094044 | ||||
|---|---|---|---|---|---|
| 説明 |
Anti-MRV-3 Sigma1/S1 Polyclonal Antibody (VK094044) is a rabbit polyclonal antibody detecting MRV-3 Sigma1/S1 in ELISA, IHC, WB. Suitable for Bacillus phage SF6 and Reovirus type 3.
Highlights
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| 種反応性 | Mammalian orthoreovirus 1 (MRV1) | ||||
| アプリケーション | ELISA, IHC, WB | ||||
| 宿主種 | Rabbit | ||||
| クローン性 | Polyclonal | ||||
| アイソタイプ | IgG | ||||
| 免疫原 | E. coli - derived recombinant MRV-3 Sigma1/S1 (Val170-Thr455). | ||||
| ターゲット | sigma-1 protein, S1 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Purified by antigen affinity column. | ||||
| アクセッション番号 | P03528, P21270 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Outer capsid protein sigma-1 (Sigma1/S1) is a ~49 kDa protein. Fiber-like molecule of about 30 nm that attaches the virion to the host cell membrane by binding with initial low affinity to sialic acid containing proteins, followed by high-affinity bindingto the entry receptor F11R/JAM-A. The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis. 1. Barton, ES. et al. (2001) Cell 104, 441-51. PMID: 11239401 2. Kirchner, E. et al. (2008) PLoS pathogens 4, e1000235. PMID: 19079583 3. Reiter, DM. et al. (2011) PLoS pathogens 7, e1002166. PMID: 21829363 | ||||
| 注意事項 | For research use only |
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