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| カタログ番号 | MC621014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MSUN2 Polyclonal Antibody (MC621014) is a rabbit polyclonal antibody detecting MSUN2 in ELISA, IHC, WB. Suitable for Mouse and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant mouse MSUN2 (Asn45-Ala431). | ||||||||
| ターゲット | D13Wsu123e, EC:2.1.1.-, EC:2.1.1.203, Misu, Myc-induced SUN domain-containing protein, NOL1/NOP2/Sun domain family member 2, Nsun2, RNA cytosine C(5)-methyltransferase NSUN2, mRNA cytosine C(5)-methyltransferase, tRNA cytosine C(5)-methyltransferase | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q1HFZ0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RNA cytosine C(5)-methyltransferase NSUN2 (MSUN2) is a ~85 kDa protein. RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. tRNA methylation is required generation of RNA fragments derived from tRNAs (tRFs). Also mediates C(5)-methylation of mitochondrial tRNAs. 1. Blanco, S. et al. (2011) PLoS genetics 7, e1002403. PMID: 22144916 2. Hussain, S. et al. (2013) Cell reports 4, 255-61. PMID: 23871666 3. Gkatza, NA. et al. (2019) PLoS biology 17, e3000297. PMID: 31199786 4. Tuorto, F. et al. (2012) Nature structural & molecular biology 19, 900-5. PMID: 22885326 5. Hussain, S. et al. (2013) Molecular and cellular biology 33, 1561-70. PMID: 23401851 6. Van Haute, L. et al. (2019) Nucleic acids research 47, 8720-8733. PMID: 31276587 | ||||||||
| 注意事項 | For research use only |
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