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| カタログ番号 | HA784014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-MTA1 Polyclonal Antibody (HA784014) is a rabbit polyclonal antibody detecting Metastasis-associated protein MTA1; MTA1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human MTA1 (Met1-Leu430). | ||||||||
| ターゲット | Metastasis-associated protein MTA1; MTA1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13330, Q8K4B0, Q62599 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Metastasis-associated protein MTA1 is a ~80 kDa protein. Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex. 1. Gururaj, AE. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 6670-5. PMID: 16617102 2. Balasenthil, S. et al. (2007) Cancer research 67, 7132-8. PMID: 17671180 3. Molli, PR. et al. (2008) Oncogene 27, 1971-80. PMID: 17922032 4. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678 5. Kang, HJ. et al. (2014) Cancer research 74, 1484-94. PMID: 24413532 6. Le Guezennec, X. et al. (2006) Molecular and cellular biology 26, 843-51. PMID: 16428440 7. Hoffmeister, H. et al. (2017) Nucleic acids research 45, 10534-10554. PMID: 28977666 8. Li, DQ. et al. (2009) The Journal of biological chemistry 284, 34545-52. PMID: 19837670 | ||||||||
| 注意事項 | For research use only |
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