

| Каталожный номер | HA784014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-MTA1 Polyclonal Antibody (HA784014) is a rabbit polyclonal antibody detecting Metastasis-associated protein MTA1; MTA1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant human MTA1 (Met1-Leu430). | ||||||||
| Цель | Metastasis-associated protein MTA1; MTA1 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q13330, Q8K4B0, Q62599 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Metastasis-associated protein MTA1 is a ~80 kDa protein. Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex. 1. Gururaj, AE. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 6670-5. PMID: 16617102 2. Balasenthil, S. et al. (2007) Cancer research 67, 7132-8. PMID: 17671180 3. Molli, PR. et al. (2008) Oncogene 27, 1971-80. PMID: 17922032 4. Cong, L. et al. (2011) The Journal of biological chemistry 286, 43793-43808. PMID: 21965678 5. Kang, HJ. et al. (2014) Cancer research 74, 1484-94. PMID: 24413532 6. Le Guezennec, X. et al. (2006) Molecular and cellular biology 26, 843-51. PMID: 16428440 7. Hoffmeister, H. et al. (2017) Nucleic acids research 45, 10534-10554. PMID: 28977666 8. Li, DQ. et al. (2009) The Journal of biological chemistry 284, 34545-52. PMID: 19837670 | ||||||||
| Примечание | For research use only |
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