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| カタログ番号 | HV819014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NANOG Polyclonal Antibody (HV819014) is a rabbit polyclonal antibody detecting NANOG in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, Pan paniscus, and Pan troglodytes.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NANOG (Trp153-Val305). | ||||||||
| ターゲット | Homeobox protein NANOG, NANOG, Homeobox transcription factor Nanog, hNanog | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H9S0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Homeobox protein NANOG is a ~34 kDa protein. Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. 1. Hayashi, Y. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 4666-71. PMID: 25825768 | ||||||||
| 注意事項 | For research use only. |
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