

| Каталожный номер | HV819014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-NANOG Polyclonal Antibody (HV819014) is a rabbit polyclonal antibody detecting NANOG in ELISA, IHC, WB. Suitable for Human, Macaca fascicularis, Pan paniscus, and Pan troglodytes.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NANOG (Trp153-Val305). | ||||||||
| Цель | Homeobox protein NANOG, NANOG, Homeobox transcription factor Nanog, hNanog | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9H9S0 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Homeobox protein NANOG is a ~34 kDa protein. Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. 1. Hayashi, Y. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 4666-71. PMID: 25825768 | ||||||||
| Примечание | For research use only. |
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