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| カタログ番号 | HT196014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NARS1 Polyclonal Antibody (HT196014) is a rabbit polyclonal antibody detecting NARS1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NARS1 (Met1-Arg330). | ||||||||
| ターゲット | Asparagine--tRNA ligase, cytoplasmic, NARS, NRS, Asparaginyl-tRNA synthetase, NARS1, Asparaginyl-tRNA synthetase 1, AsnRS | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43776 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Asparagine--tRNA ligase, cytoplasmic (NARS1) is a ~62 kDa protein. Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells. Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells. 1. Manole, A. et al. (2020) American journal of human genetics 107, 311-324. PMID: 32738225 2. Wang, L. et al. (2020) Nature communications 11, 4038. PMID: 32788587 3. Beaulande, M. et al. (1998) Nucleic acids research 26, 521-4. PMID: 9421509 4. Howard, OM. et al. (2002) The Journal of experimental medicine 196, 781-91. PMID: 12235211 5. Park, JS. et al. (2018) International journal of biological macromolecules 120, 835-845. PMID: 30171954 | ||||||||
| 注意事項 | For research use only. |
Lane 1: HepG2 cell lysate
Lane 2: K562 cell lysate
Lane 3: Hela cell lysate
Lane 4: RAW264.7 cell lysate
Lane 5: 293T cell lysate
Lane 6: LO2 cell lysate
Lane 7: Jurkat cell lysate
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