Anti-Nav1.4/Nav1.5 Na+ channel Recombinant Antibody (SAA2316) (HW585043)

Name: Anti-Nav1.4/Nav1.5 Na+ channel Recombinant Antibody (SAA2316)
Brand: abinScience
SKU: HW585043
Price: 191 USD
Availability: InStock

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Цена(USD):

Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HW585043

Реактивность видов

Human

Применения

ELISA, WB

Хозяинский вид

Human

Клоональность

Monoclonal

Изотип

VHH-Fc

ID клона

SAA2316

Цель

Sodium channel protein type 4 subunit alpha, SkM1, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, SCN4A, Sodium channel protein type 5 subunit alpha, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5, hH1, SCN5A

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P35499, Q14524

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Sodium channel protein type 4 subunit alpha (Nav1.4,Nav1.5) is a ~208 kDa protein. Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction.

1. Tsujino, A. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 7377-82. PMID: 12766226

2. Dice, MS. et al. (2004) Muscle & nerve 30, 277-88. PMID: 15318338

3. Carle, T. et al. (2006) Biochemical and biophysical research communications 348, 653-61. PMID: 16890191

4. Webb, J. et al. (2008) Neurology 70, 755-61. PMID: 17898326

5. Groome, JR. et al. (2008) Channels (Austin, Tex.) 2, 39-50. PMID: 18690054

6. Kubota, T. et al. (2009) Muscle & nerve 39, 666-73. PMID: 19347921

7. Arnold, WD. et al. (2015) Annals of neurology 77, 840-50. PMID: 25707578

8. Habbout, K. et al. (2016) Neurology 86, 161-9. PMID: 26659129

9. Zaharieva, IT. et al. (2016) Brain : a journal of neurology 139, 674-91. PMID: 26700687

10. Baroni, D. et al. (2018) Human mutation 39, 1402-1415. PMID: 29992740

Примечание

For research use only

Изображения

SDS-PAGE

SDS-PAGE for Anti-Nav1.4/Nav1.5 Na+ channel Antibody (SAA2316)

Ссылки

Даташит

Anti-Nav1.4/Nav1.5 Na+ channel Recombinant Antibody (SAA2316).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

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