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| カタログ番号 | HB843014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NCF1 Polyclonal Antibody (HB843014) is a rabbit polyclonal antibody detecting NCF1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NCF1 (Met1-Val390). | ||||||||
| ターゲット | SH3PXD1A, NCF1, p47-phox, 47 kDa autosomal chronic granulomatous disease protein, Nox-organizing protein 2, NOXO2, SH3 and PX domain-containing protein 1A, NCF-1, 47 kDa neutrophil oxidase factor, NCF-47K, Nox organizer 2, Neutrophil NADPH oxidase factor 1, Neutrophil cytosol factor 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P14598 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Neutrophil cytosol factor 1 (NCF1) is a ~44 kDa protein. Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. 1. Lomax, KJ. et al. (1989) Science (New York, N.Y.) 245, 409-12. PMID: 2547247 2. Volpp, BD. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 7195-9. PMID: 2550933 3. Liu, X. et al. (2024) Nature 627, 189-195. PMID: 38355798 4. Groemping, Y. et al. (2003) Cell 113, 343-55. PMID: 12732142 5. Kilpatrick, LE. et al. (2010) Journal of leukocyte biology 87, 153-64. PMID: 19801500 | ||||||||
| 注意事項 | For research use only. |
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