

| Numéro de catalogue | HV481014 | ||||||||
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| Description |
Anti-NCSTN Polyclonal Antibody (HV481014) is a rabbit polyclonal antibody detecting NCSTN in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human NCSTN (Gln420-Asp655). | ||||||||
| Cible | KIAA0253, Nicastrin, NCSTN | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q92542 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Nicastrin (NCSTN) is a ~78 kDa protein. Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. 1. Yu, G. et al. (2000) Nature 407, 48-54. PMID: 10993067 2. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784 3. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039 4. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335 5. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546 6. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874 | ||||||||
| Note | For research use only. |
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