Anti-Neisseria meningitidis FHBP Recombinant Antibody (1A12) (JN824013)

Name: Anti-Neisseria meningitidis FHBP Recombinant Antibody (1A12)
Brand: abinScience
SKU: JN824013
Price: 126 USD
Availability: InStock

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

JN824013

Reactivité des espèces

Neisseria meningitidis

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a

ID de clone

1A12

Cible

Factor H binding protein, fHbp, Genome-derived Neisseria antigen 1870, GNA1870, Lipoprotein 2086, LP2086, fhbP, NMB1870

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q9JXV4

RRID

Anti-Neisseria meningitidis FHBP Antibody (1A12) (abinScience Cat# JN824013, RRID:AB_3729061)
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Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Contexte

Factor H binding protein (FHBP) is a ~28 kDa protein. A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties. fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice.

1. Schneider, MC. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 7566-75. PMID: 16751403

2. Masignani, V. et al. (2003) The Journal of experimental medicine 197, 789-99. PMID: 12642606

3. Fletcher, LD. et al. (2004) Infection and immunity 72, 2088-100. PMID: 15039331

4. Giuliani, MM. et al. (2005) Infection and immunity 73, 1151-60. PMID: 15664958

5. Scarselli, M. et al. (2011) Science translational medicine 3, 91ra62. PMID: 21753121

6. Johnson, S. et al. (2012) PLoS pathogens 8, e1002981. PMID: 23133374

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Neisseria meningitidis FHBP Antibody (1A12)

Reférences

Fiche technique

Anti-Neisseria meningitidis FHBP Recombinant Antibody (1A12).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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