

| Каталожный номер | JN824013 | ||||
|---|---|---|---|---|---|
| Реактивность видов | Neisseria meningitidis | ||||
| Применения | ELISA | ||||
| Хозяинский вид | Mouse | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG2a | ||||
| ID клона | 1A12 | ||||
| Цель | Factor H binding protein, fHbp, Genome-derived Neisseria antigen 1870, GNA1870, Lipoprotein 2086, LP2086, fhbP, NMB1870 | ||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | Q9JXV4 | ||||
| RRID | Anti-Neisseria meningitidis FHBP Antibody (1A12) (abinScience Cat# JN824013, RRID:AB_3729061) |
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| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| Фон | Factor H binding protein (FHBP) is a ~28 kDa protein. A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties. fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice. 1. Schneider, MC. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 7566-75. PMID: 16751403 2. Masignani, V. et al. (2003) The Journal of experimental medicine 197, 789-99. PMID: 12642606 3. Fletcher, LD. et al. (2004) Infection and immunity 72, 2088-100. PMID: 15039331 4. Giuliani, MM. et al. (2005) Infection and immunity 73, 1151-60. PMID: 15664958 5. Scarselli, M. et al. (2011) Science translational medicine 3, 91ra62. PMID: 21753121 6. Johnson, S. et al. (2012) PLoS pathogens 8, e1002981. PMID: 23133374 | ||||
| Примечание | For research use only. |

SDS-PAGE for Anti-Neisseria meningitidis FHBP Antibody (1A12)
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