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| カタログ番号 | JN824053 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Neisseria meningitidis | ||||||
| アプリケーション | ELISA, WB | ||||||
| 宿主種 | Human | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG1, kappa | ||||||
| クローンID | SAA2741 | ||||||
| ターゲット | Factor H binding protein, GNA1870, Genome-derived Neisseria antigen 1870, LP2086, Lipoprotein 2086, fHbp, fhbP | ||||||
| エンドトキシンレベル | < 10 EU/mg | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | Q9JXV4 | ||||||
| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 背景 | Factor H binding protein (FHBP) is a ~28 kDa protein. A bacterial surface lipoprotein that binds host (human) complement factor H (fH, gene CFH), binding contributes to the avoidance of complement-mediated lysis by N.meningitidis. Binding of fH to the bacteria surface is independent of bacterial sialic acid moieties. fH binding affinity is high enough that it may sequester plasma fH, depleting its circulating levels and de-regulating complement in the host (Probable). This protein induces high levels of bactericidal antibodies in mice. 1. Schneider, MC. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 7566-75. PMID: 16751403 2. Masignani, V. et al. (2003) The Journal of experimental medicine 197, 789-99. PMID: 12642606 3. Fletcher, LD. et al. (2004) Infection and immunity 72, 2088-100. PMID: 15039331 4. Giuliani, MM. et al. (2005) Infection and immunity 73, 1151-60. PMID: 15664958 5. Scarselli, M. et al. (2011) Science translational medicine 3, 91ra62. PMID: 21753121 6. Johnson, S. et al. (2012) PLoS pathogens 8, e1002981. PMID: 23133374 | ||||||
| 注意事項 | For research use only |
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