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| カタログ番号 | HV994014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NEU4 Polyclonal Antibody (HV994014) is a rabbit polyclonal antibody detecting NEU4 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NEU4 (Tyr22-Pro286). | ||||||||
| ターゲット | Sialidase-4, NEU4, N-acetyl-alpha-neuraminidase 4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8WWR8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sialidase-4 (NEU4) is a ~51 kDa protein. Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose. 1. Seyrantepe, V. et al. (2004) The Journal of biological chemistry 279, 37021-9. PMID: 15213228 2. Yamaguchi, K. et al. (2005) The Biochemical journal 390, 85-93. PMID: 15847605 3. Shiozaki, K. et al. (2011) The Journal of biological chemistry 286, 21052-61. PMID: 21521691 | ||||||||
| 注意事項 | For research use only. |
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