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| カタログ番号 | HV001014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NLRP3 Polyclonal Antibody (HV001014) is a rabbit polyclonal antibody detecting NLRP3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NLRP3 (Met1-Arg157). | ||||||||
| ターゲット | NLRP3, NACHT, LRR and PYD domains-containing protein 3, Caterpiller protein 1.1, C1orf7, PYPAF1, PYRIN-containing APAF1-like protein 1, CIAS1, CLR1.1, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, Angiotensin/vasopressin receptor AII/AVP-like, NALP3 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96P20 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | NACHT, LRR and PYD domains-containing protein 3 (NLRP3) is a ~118 kDa protein. Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis. In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC. Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis. Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses. Involved in the homeostatic wound healing response to tissue injury, a multistep cascade that guides neutrophil migration to necrotic sites while avoiding collateral damage of healthy tissues. 1. Martinon, F. et al. (2006) Nature 440, 237-41. PMID: 16407889 2. Dostert, C. et al. (2008) Science (New York, N.Y.) 320, 674-7. PMID: 18403674 3. Hornung, V. et al. (2008) Nature immunology 9, 847-56. PMID: 18604214 4. Subramanian, N. et al. (2013) Cell 153, 348-61. PMID: 23582325 5. Coll, RC. et al. (2015) Nature medicine 21, 248-55. PMID: 25686105 6. Song, H. et al. (2016) Nature communications 7, 13727. PMID: 27929086 7. Li, X. et al. (2017) Nature communications 8, 15986. PMID: 28656979 8. Nakanishi, H. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E7766-E7775. PMID: 28847925 9. Chen, J. et al. (2018) Nature 564, 71-76. PMID: 30487600 10. Mehto, S. et al. (2019) Molecular cell 73, 429-445.e7. PMID: 30612879 | ||||||||
| 注意事項 | For research use only. |
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