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| カタログ番号 | HX241014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NME5 (Ile3-Lys194). | ||||||||
| ターゲット | nm23-H5, Testis-specific nm23 homolog, NDK-H 5, Inhibitor of p53-induced apoptosis-beta, NME5, NDP kinase homolog 5, IPIA-beta, Nucleoside diphosphate kinase homolog 5 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P56597 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nucleoside diphosphate kinase 5 (NME5) is a ~24 kDa protein. Functions as part of axonemal radial spoke complexes, which play an important part in the motility of sperm and cilia. In vitro, does not display nucleoside diphosphate kinase (NDPK) activity (Probable). Exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. Confers protection from cell death mediated by BAX and alters the cellular levels of several antioxidant enzymes, including GPX5. Might be involved in spermiogenesis by enhancing the ability of late-stage spermatids to eliminate reactive oxygen species. 1. Yoon, JH. et al. (2005) Biochemistry 44, 15774-86. PMID: 16313181 2. Munier, A. et al. (1998) FEBS letters 434, 289-94. PMID: 9742940 | ||||||||
| 注意事項 | For research use only. |
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