

| Каталожный номер | HX241014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NME5 (Ile3-Lys194). | ||||||||
| Цель | nm23-H5, Testis-specific nm23 homolog, NDK-H 5, Inhibitor of p53-induced apoptosis-beta, NME5, NDP kinase homolog 5, IPIA-beta, Nucleoside diphosphate kinase homolog 5 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P56597 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Nucleoside diphosphate kinase 5 (NME5) is a ~24 kDa protein. Functions as part of axonemal radial spoke complexes, which play an important part in the motility of sperm and cilia. In vitro, does not display nucleoside diphosphate kinase (NDPK) activity (Probable). Exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. Confers protection from cell death mediated by BAX and alters the cellular levels of several antioxidant enzymes, including GPX5. Might be involved in spermiogenesis by enhancing the ability of late-stage spermatids to eliminate reactive oxygen species. 1. Yoon, JH. et al. (2005) Biochemistry 44, 15774-86. PMID: 16313181 2. Munier, A. et al. (1998) FEBS letters 434, 289-94. PMID: 9742940 | ||||||||
| Примечание | For research use only. |
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