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| カタログ番号 | HV077014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NOD1 Polyclonal Antibody (HV077014) is a rabbit polyclonal antibody detecting NOD1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NOD1 (Ala612-Asp826). | ||||||||
| ターゲット | NOD1, Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4, CARD4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y239 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a ~107 kDa protein. Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses. Specifically recognizes and binds gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria. Preferentially binds iE-DAP in tripeptide-containing muropeptides (MurNAc-TriDAP or TriDAP). Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2. Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling. 1. Inohara, N. et al. (2001) The Journal of biological chemistry 276, 2551-4. PMID: 11058605 2. Girardin, SE. et al. (2003) Science (New York, N.Y.) 300, 1584-7. PMID: 12791997 3. Chamaillard, M. et al. (2003) Nature immunology 4, 702-7. PMID: 12796777 4. Tanabe, T. et al. (2004) The EMBO journal 23, 1587-97. PMID: 15044951 5. Girardin, SE. et al. (2005) The Journal of biological chemistry 280, 38648-56. PMID: 16172124 6. Fukazawa, A. et al. (2008) PLoS pathogens 4, e1000228. PMID: 19043560 7. Lautz, K. et al. (2012) Cellular microbiology 14, 1568-83. PMID: 22672233 8. Vegna, S. et al. (2016) Journal of virology 90, 6022-6035. PMID: 27099311 10. Magalhaes, JG. et al. (2005) EMBO reports 6, 1201-7. PMID: 16211083 | ||||||||
| 注意事項 | For research use only. |
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