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| カタログ番号 | HF591014 | ||||||||
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| 説明 |
Anti-NOS1AP Polyclonal Antibody (HF591014) is a rabbit polyclonal antibody detecting NOS1AP in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NOS1AP (Thr285-Val506). | ||||||||
| ターゲット | Nitric oxide synthase 1 adaptor protein, NOS1AP, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, KIAA0464, CAPON, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75052 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP) is a ~56 kDa protein. Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation. 1. Majmundar, AJ. et al. (2021) Science advances 7. PMID: 33523862 | ||||||||
| 注意事項 | For research use only. |
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