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| カタログ番号 | HV105014 | ||||||||
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| 説明 |
Anti-NOSIP Polyclonal Antibody (HV105014) is a rabbit polyclonal antibody detecting NOSIP in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Macaca fascicularis.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NOSIP (Gly62-Ser295). | ||||||||
| ターゲット | eNOS-interacting protein, NOSIP, RING-type E3 ubiquitin transferase NOSIP, Nitric oxide synthase-interacting protein, E3 ubiquitin-protein ligase NOSIP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y314 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nitric oxide synthase-interacting protein (NOSIP) is a ~33 kDa protein. E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity. 1. Dedio, J. et al. (2001) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 15, 79-89. PMID: 11149895 2. Dreyer, J. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 10454-65. PMID: 15548660 3. Schleicher, M. et al. (2005) Molecular and cellular biology 25, 8251-8. PMID: 16135813 | ||||||||
| 注意事項 | For research use only. |
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