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| カタログ番号 | HV351014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NOTCH2NLA Polyclonal Antibody (HV351014) is a rabbit polyclonal antibody detecting NOTCH2NLA in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NOTCH2NLA (Met1-Asn236). | ||||||||
| ターゲット | Notch homolog 2 N-terminal-like protein A, NOTCH2NL, Notch homolog 2 N-terminal-like protein, N2N, NOTCH2NLA | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q7Z3S9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) is a ~25 kDa protein. Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. 1. Florio, M. et al. (2018) eLife 7. PMID: 29561261 2. Fiddes, IT. et al. (2018) Cell 173, 1356-1369.e22. PMID: 29856954 3. Suzuki, IK. et al. (2018) Cell 173, 1370-1384.e16. PMID: 29856955 | ||||||||
| 注意事項 | For research use only. |
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