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| カタログ番号 | HT011024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NPC1 Polyclonal Antibody (HT011024) is a rabbit polyclonal antibody detecting NPC1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NPC1 (Arg372-Phe622). | ||||||||
| ターゲット | NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15118 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | NPC intracellular cholesterol transporter 1 (NPC1) is a ~142 kDa protein. Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). 1. Davies, JP. et al. (2000) The Journal of biological chemistry 275, 24367-74. PMID: 10821832 2. Blom, TS. et al. (2003) Human molecular genetics 12, 257-72. PMID: 12554680 3. Infante, RE. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15287-92. PMID: 18772377 4. Gong, X. et al. (2016) Cell 165, 1467-1478. PMID: 27238017 5. Carstea, ED. et al. (1997) Science (New York, N.Y.) 277, 228-31. PMID: 9211849 6. Watari, H. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 805-10. PMID: 9927649 7. Kwon, HJ. et al. (2009) Cell 137, 1213-24. PMID: 19563754 8. Ebrahimi-Fakhari, D. et al. (2016) Human molecular genetics 25, 3588-3599. PMID: 27378690 | ||||||||
| 注意事項 | For research use only. |
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