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| カタログ番号 | HY577014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-NPM1 Polyclonal Antibody (HY577014) is a rabbit polyclonal antibody detecting NPM1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NPM1 (Gly20-Lys154). | ||||||||
| ターゲット | NPM, Nucleolar protein NO38, Numatrin, NPM1, Nucleolar phosphoprotein B23, Nucleophosmin | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P06748 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nucleophosmin (NPM1) is a ~32 kDa protein. Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. 1. Liu, X. et al. (2012) The Journal of biological chemistry 287, 19599-609. PMID: 22528486 2. Kim, JY. et al. (2015) The American journal of pathology 185, 2061-8. PMID: 25956029 | ||||||||
| 注意事項 | For research use only. |
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