Anti-NPPB Polyclonal Antibody (HB840014)

Name: Anti-NPPB Polyclonal Antibody
Brand: abinScience
SKU: HB840014
Price: 168 USD
Availability: InStock

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概要
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概要

カタログ番号

HB840014

説明

Anti-NPPB Polyclonal Antibody (HB840014) is a rabbit polyclonal antibody detecting NPPB in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

種反応性

Human

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human NPPB (His27-Arg102).

ターゲット

NT-proBNP(1-76), preproBNP, BNP(1-32), BNP(4-32), proBNP, Brain natriuretic peptide, BNP, des-SerPro-BNP, NPPB, NT-pro-BNP, proBNP(79-108), Iso-ANP, Natriuretic peptides B, Gamma-brain natriuretic peptide, Brain natriuretic factor prohormone, BNP-32

精製

Purified by antigen affinity column.

アクセッション番号

P16860

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Natriuretic peptides B (NPPB/BNP) is a ~14 kDa protein. Cardiac hormone that plays a key role in mediating cardio-renal homeostasis. May also function as a paracrine antifibrotic factor in the heart. Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.

1. Koller, KJ. et al. (1991) Science (New York, N.Y.) 252, 120-3. PMID: 1672777

2. Heublein, DM. et al. (2007) Hypertension (Dallas, Tex. : 1979) 49, 1114-9. PMID: 17372040

3. Yoshimura, M. et al. (1991) Circulation 84, 1581-8. PMID: 1914098

4. Jensen, KT. et al. (1998) The American journal of physiology 274, F63-72. PMID: 9458824

5. Liang, F. et al. (2007) Journal of the American College of Cardiology 49, 1071-8. PMID: 17349887

6. Ralat, LA. et al. (2011) The Journal of biological chemistry 286, 4670-9. PMID: 21098034

7. Huntley, BK. et al. (2015) Circulation. Heart failure 8, 89-97. PMID: 25339504

注意事項

For research use only.

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参考文献

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